Neural injections of Bromodeoxyuridine (BrdU) were applied to males of both groups to test for neurogenesis . Analysis showed that testosterone and dihydrotestosterone regulated adult hippocampal neurogenesis (AHN). Adult hippocampal neurogenesis was regulated through the androgen receptor in the wild-type male rats, but not in the TMF male rats. To further test the role of activated androgen receptors on AHN, flutamide , an antiandrogen drug that competes with testosterone and dihydrotestosterone for androgen receptors , and dihydrotestosterone were administered to normal male rats. Dihydrotestosterone increased the number of BrdU cells, while flutamide inhibited these cells.
While it’s common for bodybuilders to suspect that Anadrol would be an even riskier choice for use by women than most anabolic steroids, actually the reverse is true. Medically, once per day dosing of 50 mg/day over extended periods has shown only a moderate rate of virilization problems . The same certainly cannot be said of Anavar , Dianabol, or Winstrol ( stanozolol .) While not necessarily sufficient for high level female bodybuilding competition by today’s standards, such a dose actually is considerably more than needed by most women for excellent results in adding muscle, losing fat, and generally improving their physiques. Half this dose — 25 mg/day, preferably taken as divided doses — is very effective and is so far as I know the lowest-risk way to obtain this degree of benefit from anabolic steroids.