Carbamazepine has been shown to have adverse effects in reproduction studies in rats when given orally in dosages 10 to 25 times the maximum human daily dosage (MHDD) of 1200 mg on a mg/kg basis or to 4 times the MHDD on a mg/m 2 basis. In rat tera tology studies, 2 of 135 offspring showed kinked ribs at 250 mg/kg and 4 of 119 offspring at 650 mg/kg showed other anomalies (cleft palate, 1; talipes, 1; anophthal mos, 2). In reproduction studies in rats, nursing offspring demonstrated a lack of weight gain and an unkempt appearance at a maternal dosage level of 200 mg/kg.
In the single-arm trial, 48% of patients (n = 62) were ≥ 65 years of age and 10% of patients (n=13) were ≥ 75 years of age [See Clinical Studies ]. The median age of the trial population was 63 years. Patients ≥ 65 years of age had a higher response rate to Beleodaq treatment than patients < 65 years of age (36% versus 16%) while no meaningful differences in response rate were observed between patients ≥ 75 years of age and those < 75 years of age. No clinically meaningful differences in serious adverse reactions were observed in patients based on age (< 65 years compared with ≥ 65 years or < 75 years of age compared with ≥ 75 years of age).
Different testosterone esters are often blended into one injectable preparation. In some cases up to seven esters are used, but the most popular formulation is that of Sustanon 250 where four esters are mixed together. This is done to take advantage of the faster acting esters while still only requiring weekly or bi-weekly injections. It is often believed to be a superior form of testosterone, but in reality it’s nothing more than just testosterone. One drawback of testosterone blends are that they incorporate esters with long carbon chains and those chains occupy allot of molecular weight, so the actual dosage of hormone is less than one would obtain from shorter esters like propionate. Testosterone blends are most useful during bulking phases where frequent injections are not possible.