Referring to Figure 1, carbon monoxide is supplied via a line 1, a line 2 and a line 3, ethylene via a line 4 and the line 3, methanol via a line 5 and a line 6 and a catalytic system via a line 7, a line 8 and the line 6 to a reactor 9. Compressed recycle gas is conducted via a line 10 and the lines 2 and 3 to the reactor 9. A recycle of azeotrope is conducted via a line 11 to the line 8. The reactor 9 is provided with a stirrer 12 and cooling means 13. The temperature in the reactor is 110°C, the pressure is 40 bar and the residence time of the reaction mixture 2 hours.
The pharmacodynamic variability in plasma testosterone and inhibin concentrations is accounted for by the variability between esters and the site and volume of injection of the nandrolone injections. The overall kinetics of suppression of testosterone is dominated by the slow negative feedback system, rather than the much faster metabolic clearance of testosterone. This negative feedback is mediated via inhibition of pulsatile gonadotropin-releasing hormone secretion from hypothalamic neurons into the pituitary portal system and then pituitary LH secretion from gonadotropes. This is in stark contrast to a highly potent and specific gonadotropin-releasing hormone antagonist that causes immediate cessation of gonadotropin-releasing hormone action leading to castrate testosterone concentrations within 12 hr, compared with 5 to 10 days with AAS administration. After a single 100 mg injection of NPP, recovery takes 10+ days. After ND, recovery takes 15+ days. It is important to note these are single administrations of 100 mg. HPTA recovery with repeated doses of 200+ mg is long!!!! (3, 8)
Androgens are responsible for the growth spurt of adolescence and the aromatization of androgens to estrogens for the eventual termination of linear growth, which is brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoietin stimulating factor.