Healing has to be interrupted till these consequnces have disappeared, after which treatment has to be followed at a lower dose.
Hoarseness of the voice may be the first symptom of vocal change which can lead to irreversible lowering of the voice. In case signs of virilisation advance, particularly lowering of the voice, treatment must be stopped unless the consequnces are desired management outcomes.
The following negative effects have also been known:
– disorders of liver function
– weight put (in female-to-male transsexuals)
Testosterone can be administered parenterally , but it has more irregular prolonged absorption time and greater activity in muscle in enanthate , undecanoate , or cypionate ester form. These derivatives are hydrolyzed to release free testosterone at the site of injection; absorption rate (and thus injection schedule) varies among different esters, but medical injections are normally done anywhere between semi-weekly to once every 12 weeks. A more frequent schedule may be desirable in order to maintain a more constant level of hormone in the system.  Injectable steroids are typically administered into the muscle, not into the vein, to avoid sudden changes in the amount of the drug in the bloodstream. In addition, because estered testosterone is dissolved in oil, intravenous injection has the potential to cause a dangerous embolism (clot) in the bloodstream.