One of these, PX-866 , has been shown to be a novel, potent, irreversible, inhibitor of PI-3 kinase with efficacy when delivered orally. PX-866 was put in a phase 1 clinical trial by Oncothyreon company.    The clinical development plan for PX-866 includes both standalone and combination therapy in major human cancers.  In 2010 PX-866 was starting 4 phase II trials for solid tumours.  The company gave an update on its phase 2 trials in Jun 2012.  Phase 1 results (with docetaxel) published Aug 2013.  In July 2014 published results of a phase 2 trial (for NSCLC) concluded : "The addition of PX-866 to docetaxel did not improve PFS, response rate, or OS in patients with advanced, refractory NSCLC without molecular preselection".  In Sept 2015 as Phase 2 trial for recurrent glioblastoma reported not meeting its primary endpoint. 
If treating the depression does not improve libido, other causes of sexual dysfunction should be considered, such as hormone deficiencies, chronic disease, drug and alcohol abuse, or use of other medications. Evidence supports several treatment options in patients who experience sexual dysfunction or decreased libido as a consequence of anti-depressant use. These include decreasing the dosage of an SSRI or tricyclic antidepressant, instigating medication holidays, adding or switching to bupropion, and using nefazodone as an alternative agent. Cause and effect may not be clear, but addressing sexual desire when treating depression may improve compliance and overall outcome.
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