When Hexarelin is given as a subcutaneous injection, it activates the pituitary via a pulse, just like GHRP-6, and helps circulate growth hormone in the body. Unlike GHRP-6, it does not induce any hunger side effects. Hexarelin has the ability to not only raise the level of GH in the body but to also suppress somatostatin, which is the main culprit that inhibits GH from being released. This means that there will be more GH in abundance. In addition, hexarelin is the strongest GHRP available, so users should notice that desensitization can come much quicker than other GHRP’s. This makes it less ideal for long term use, but with hexarelin’s ability to raise healthy levels of IGF-1 and GH it can work perfect as a PCT tool for those coming off a synthetic GH/IGF-1 cycle. The potency of this peptide should not be underestimated and it comes with an increase in cortisol production as well as prolactin. Nothing close to what might be seen in elevated levels from steroid use, but compared to other GHRP’s it has the strongest affinity to raise cortisol/prolactin.
GHRP-6 and the Growth Hormone Secretagogue Receptor
GHRPs are not simply surrogates of GHRH, instead GHRP-6 is an artificial activator of a separate newly discovered receptor called Growth Hormone Secretagogue Receptor (GHS-R). Soon Ghrelin was discovered, the endogenous ligand that binds to the GHS-R. Both Ghrelin and all the synthetic compounds such as GHRP-6 were termed “Growth Hormone Secretagogues” (GHSs). One side effect of GHRP-6 is a significant increase in appetite due to stimulating the release of Ghrelin, a peptide that is released naturally in the lining of the stomach that increases hunger and gastric emptying. Also, GHRP-6 causes stimulation of the anterior pituitary gland which causes an increase in Growth Hormone release. The increased amounts of Growth Hormone can cause the liver to secrete the hormone IGF-1, which improves the animal body’s ability to burn fat and build muscle. Since GHRP-6 acts directly on the feedback loop which signals the inhibition of Growth Hormone release, GHRP-6 can re-stimulate the production of Growth Hormone.
As alluded to above, one very important thing to acknowledge when using AAS (whether taking one hormone, stacking or cycling) is the risk of harmful side effects. Within a steroid cycle, the users will often stack other non-anabolic hormones into their program to maximize specific cycle objectives for example: the addition of drugs like Clenbuterol and/or Cytomel /T3 augment cutting/definition cycles; others called aromatase inhibitors (estrogen reducing drugs) like Letrozole . Letro and Anastrozole Arimidex are often included to inhibit the conversion of excess testosterone to negatively cycle impacting estrogen and; incorporating post-cycle therapy (PCT) drugs such as the synthetic estrogens Tamoxifen . Nolvadex , or Clomiphene Citrate . Clomid (which act as anti-estrogens in the male body), can be used alone, together, or in conjunction with those like Mesterolone . Proviron and Human Chorionic Gonadotropin ( HCG ) during PCT to bridge the gap between the end of a steroid cycle (synthetic testosterone usage) and the restoration of the bodys natural testosterone production. These drugs too must be researched, and controlled in similar fashion to AAS. Thus, steroid cycles can be as simple or complex as the users individualized goals, cycle histories and levels of understanding. Below are three samples of AAS stacked cycles of varying complexity along with a beginning PCT sample, and an explanation of goal intention & rationale for the selected compounds, dosages & durations. These illustrations and commentaries will provide a better understanding of what stacking and cycling are along with the many nuances they require.